Photo by Michael True
Hotels in Defiance
Free cancellation options if plans change
Earn rewards on every night you stay
Save more with Member Prices
Check prices for these dates
Where to stay in Defiance?

The Wildwood Hotel
The Wildwood Hotel
9.2 out of 10, Wonderful, (1591)
The price is $88
$107 total
includes taxes & fees
Oct 26 - Oct 27
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Go beyond your typical stay in Defiance
Apartment
Top landmarks in Defiance
Learn more about Defiance
Defiance is well-known for its attractions such as Yellow Farmhouse Winery and Chandler Hill Vineyards.

Check out reviews of Defiance hotels guests love

Drury Inn & Suites Southwest St. Louis
10/10 Excellent
Frequently asked questions
Keep exploring
- Landmarks
- Hotels close to nearby airports
- Nearby cities
- Top cities in United States of America
- More Hotels
- Hotels near Hollywood Casino Amphitheatre
- Hotels near Matson Hill Park Trailhead
- Hotels near August A. Busch Memorial Conservation Area
- Hotels near Chandler Hill Vineyards
- Hotels near Historic Daniel Boone Home and Heritage Center
- Hotels near Sugar Creek Winery
- Hotels near Yellow Farmhouse Winery
- Hotels near Broemmelsiek Park
- Hotels near Hamburg Trail Trailhead
- Hotels near Ameristar Casino St. Charles
- Hotels near Westport Plaza
- Hotels near Hollywood Casino
- Hotels near St Charles Convention Center
- Hotels near Route 66 State Park
- Hotels near Magic House - St. Louis Children's Museum
- Hotels near Historic Main Street
- Hotels near Purina Farms
- Hotels near Lindenwood University
- Hotels near St. Louis Premium Outlets
- Hotels near Family Arena
- New York Hotels
- Las Vegas Hotels
- Orlando Hotels
- Chicago Hotels
- San Francisco Hotels
- Los Angeles Hotels
- San Diego Hotels
- Houston Hotels
- Boston Hotels
- Miami Hotels
- Pigeon Forge Hotels
- Nashville Hotels
- Gatlinburg Hotels
- Atlanta Hotels
- San Antonio Hotels
- Honolulu Hotels
- Austin Hotels
- New Orleans Hotels
- Myrtle Beach Hotels
- Seattle Hotels
- Hilton St. Louis Frontenac
- Crowne Plaza St. Louis Airport by IHG
- Comfort Inn St. Louis - Westport Event Center
- Courtyard by Marriott St Louis Westport Plaza
- Sonesta Simply Suites St Louis Earth City
- Marriott St. Louis West
- Comfort Suites St Charles - St Louis
- Best Western Plus Fenton
- Holiday Inn Express & Suites St. Louis West - Fenton by IHG
- Country Inn & Suites by Radisson, St. Charles Historic District
- Relax Inn Saint Charles
- Embassy Suites by Hilton St. Louis St. Charles
- Best Western Plus The Charles Hotel
- Courtyard St. Louis Airport/Earth City
- Country Inn & Suites by Radisson, St. Peters, MO
- Drury Plaza Hotel St. Louis St. Charles
- Super 8 by Wyndham St Charles
- Sleep Inn & Suites O'Fallon MO - Technology Drive
- AC Hotel by Marriott St. Louis Chesterfield
- Courtyard by Marriott St. Louis Chesterfield
- Embassy Suites by Hilton St. Louis Airport
- Drury Inn & Suites St. Louis St. Peters
- Holiday Inn St. Louis Arpt West-Earth City by IHG
- Holiday Inn Express & Suites St. Louis - Chesterfield by IHG
- Candlewood Suites St Louis St Charles by IHG
- Hilton Garden Inn Chesterfield
- Hampton Inn St. Louis/Chesterfield
- Comfort Inn & Suites St. Louis - O'Fallon
- Staybridge Suites O'Fallon Chesterfield by IHG
- Homewood Suites by Hilton St. Louis-Chesterfield
- Holiday Inn St. Louis West Six Flags by IHG
- Hampton Inn & Suites St. Charles Old Town Area
- Extended Stay America Suites St Louis St Peters
- Red Roof Inn St Louis - Westport/ Maryland Heights
- Comfort Inn St. Louis Airport
- Comfort Inn & Suites Chesterfield - St. Louis
- Tru by Hilton St. Charles St. Louis, MO
- SpringHill Suites by Marriott St. Louis Airport/Earth City
- Hampton Inn St. Louis/Westport
- Days Inn by Wyndham St Peters/St Charles
- Fairfield Inn & Suites St Louis Westport
- Courtyard by Marriott St. Louis St. Peters
- Sheraton Westport Plaza Hotel St. Louis
- Holiday Inn Express St. Louis West - O'Fallon by IHG
- Fairfield Inn & Suites by Marriott St. Louis Chesterfield
- Staybridge Suites St Louis - Westport by IHG
- Extended Stay America Suites St Louis Westport Central
- Courtyard by Marriott St. Louis West County
- Motel 6 Maryland Heights, MO
- Holiday Inn Express & Suites St Peters by IHG