Hotels in Defiance

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Check prices for these dates

Tonight
Jul 19 - Jul 20
Tomorrow
Jul 20 - Jul 21
Next weekend
Jul 25 - Jul 27
In two weeks
Aug 1 - Aug 3

Where to stay in Defiance?

Drury Inn & Suites St. Louis St. Peters
Enjoy meals and drinks in this outdoor dining area with a view of the interior.

Drury Inn & Suites St. Louis St. Peters

3.0 star property
9.2 out of 10, Wonderful, (1005)
The price is $107
$123 total
includes taxes & fees
Aug 17 - Aug 18
Drury Inn & Suites St. Louis St. Peters
Sleep Inn & Suites O'Fallon MO - Technology Drive
Welcome to our hotel lobby, featuring a reception desk, comfortable seating area, and stylish rug.

Sleep Inn & Suites O'Fallon MO - Technology Drive

2.5 star property
8.8 out of 10, Excellent, (1007)
The price is $89
$105 total
includes taxes & fees
Jul 27 - Jul 28
Sleep Inn & Suites O'Fallon MO - Technology Drive
The Wildwood Hotel
Enjoy a romantic dinner for two with fine china, linens, and elegant table settings.

The Wildwood Hotel

3.5 star property
9.2 out of 10, Wonderful, (1551)
The price is $92
$111 total
includes taxes & fees
Jul 28 - Jul 29
The Wildwood Hotel
Drury Inn & Suites Southwest St. Louis
Relax in the hotel lobby's central seating area, featuring a sofa and armchairs, a flat-screen TV, and a large window.

Drury Inn & Suites Southwest St. Louis

3.0 star property
9.4 out of 10, Exceptional, (1000)
The price is $115
$135 total
includes taxes & fees
Aug 10 - Aug 11
Drury Inn & Suites Southwest St. Louis
LAKEVIEWINN
Experience the stylish entrance of our hotel, marked by a prominent sign and flanked by double doors with glass panels.

LAKEVIEWINN

2.5 star property
5.0 out of 10, (16)
The price is $77
$86 total
includes taxes & fees
Jul 25 - Jul 26
LAKEVIEWINN
Super 8 by Wyndham Washington
Two single beds with white linens and brown borders, a flat-screen TV, and a large abstract artwork adorn this stylish room.

Super 8 by Wyndham Washington

2.0 star property
8.4 out of 10, Very Good, (658)
The price is $90
$103 total
includes taxes & fees
Jul 27 - Jul 28
Super 8 by Wyndham Washington
Comfort Inn & Suites St. Louis - O'Fallon
Welcome to our reception area, featuring a granite reception desk, framed artworks, and comfortable seating.

Comfort Inn & Suites St. Louis - O'Fallon

2.5 star property
7.6 out of 10, Good, (1000)
The price is $90
$106 total
includes taxes & fees
Jul 20 - Jul 21
Comfort Inn & Suites St. Louis - O'Fallon
Best Western Plus Washington Hotel
Relax in comfort with a large bed and desk area featuring a TV.

Best Western Plus Washington Hotel

2.5 star property
9.0 out of 10, Wonderful, (577)
The price is $129
$147 total
includes taxes & fees
Jul 20 - Jul 21
Best Western Plus Washington Hotel
Holiday Inn Express & Suites St. Louis - Chesterfield by IHG
Enjoy a variety of food options at our self-service buffet with multiple stations.

Holiday Inn Express & Suites St. Louis - Chesterfield by IHG

2.5 star property
9.2 out of 10, Wonderful, (911)
The price is $118
$137 total
includes taxes & fees
Jul 27 - Jul 28
Holiday Inn Express & Suites St. Louis - Chesterfield by IHG
Quality Inn
Relax in the stylish lobby with a central seating area, herringbone-patterned floor, and large windows offering a view of the outdoors.

Quality Inn

2.5 star property
8.2 out of 10, Very Good, (810)
The price is $94
$106 total
includes taxes & fees
Aug 18 - Aug 19
Quality Inn
Hampton Inn St. Louis/Chesterfield
Swim laps in the pool surrounded by windows and a ladder for easy access.

Hampton Inn St. Louis/Chesterfield

3.5 star property
8.6 out of 10, Excellent, (1002)
The price is $99
$115 total
includes taxes & fees
Aug 15 - Aug 16
Hampton Inn St. Louis/Chesterfield
Holiday Inn Express & Suites St Peters by IHG
Welcome to our lobby, featuring a reception desk, comfortable seating area, and dining space.

Holiday Inn Express & Suites St Peters by IHG

2.5 star property
9.2 out of 10, Wonderful, (324)
The price is $85
$104 total
includes taxes & fees
Aug 10 - Aug 11
Holiday Inn Express & Suites St Peters by IHG
Courtyard by Marriott St. Louis Chesterfield
Relax in style with comfortable wicker sofas and chairs surrounding a central fire feature.

Courtyard by Marriott St. Louis Chesterfield

3.0 star property
9.0 out of 10, Wonderful, (538)
The price is $101
$118 total
includes taxes & fees
Jul 27 - Jul 28
Courtyard by Marriott St. Louis Chesterfield
Hampton Inn & Suites St. Louis/Chesterfield
Stunning hotel entrance with a covered walkway leading to the main building, surrounded by beautifully maintained gardens.

Hampton Inn & Suites St. Louis/Chesterfield

3.5 star property
8.6 out of 10, Excellent, (794)
The price is $101
$118 total
includes taxes & fees
Aug 3 - Aug 4
Hampton Inn & Suites St. Louis/Chesterfield
Hilton Garden Inn St. Louis/O'Fallon MO
Relax in our spacious lobby with comfortable seating and a warm atmosphere.

Hilton Garden Inn St. Louis/O'Fallon MO

3.0 star property
8.8 out of 10, Excellent, (690)
The price is $143
$170 total
includes taxes & fees
Aug 1 - Aug 2
Hilton Garden Inn St. Louis/O'Fallon MO
Holiday Inn Express St. Louis West - O'Fallon by IHG
Hotel features a modern design with a combination of brick and neutral-toned facades, multiple windows, and a covered entrance.

Holiday Inn Express St. Louis West - O'Fallon by IHG

2.5 star property
8.6 out of 10, Excellent, (735)
The price is $112
$132 total
includes taxes & fees
Jul 27 - Jul 28
Holiday Inn Express St. Louis West - O'Fallon by IHG
Wingate by Wyndham St. Louis/Fenton Route 66
Two single beds with white linens and a patterned bed runner, each with a bedside table and lamp.

Wingate by Wyndham St. Louis/Fenton Route 66

3.0 star property
8.4 out of 10, Very Good, (1014)
The price is $89
$103 total
includes taxes & fees
Jul 20 - Jul 21
Wingate by Wyndham St. Louis/Fenton Route 66
Heritage Inn & Suites St. Louis/Fenton, Trademark by Wyndham
Relax in the stylish lobby, featuring a cozy seating area with a patterned ottoman and armchairs, a geometric-patterned rug, and a large window with a view.

Heritage Inn & Suites St. Louis/Fenton, Trademark by Wyndham

3.0 star property
8.4 out of 10, Very Good, (1005)
The price is $94
$109 total
includes taxes & fees
Aug 3 - Aug 4
Heritage Inn & Suites St. Louis/Fenton, Trademark by Wyndham
River Sirens Hotel
Enjoy a compact room with a kitchenette, bed with integrated lighting, and a seating area with a table and chair.

River Sirens Hotel

2.5 star property
9.8 out of 10, Exceptional, (159)
The price is $133
$152 total
includes taxes & fees
Jul 20 - Jul 21
River Sirens Hotel
Super 8 by Wyndham Eureka/Six Flags Nearby
Guests can enter the hotel through the covered entrance area, which features a ramp for easy access.

Super 8 by Wyndham Eureka/Six Flags Nearby

2.0 star property
7.0 out of 10, Good, (1001)
The price is $66
$77 total
includes taxes & fees
Aug 10 - Aug 11
Super 8 by Wyndham Eureka/Six Flags Nearby
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Top landmarks in Defiance

August A. Busch Memorial Conservation Area

August A. Busch Memorial Conservation Area

If you like spending time outside, why not spend the afternoon at August A. Busch Memorial Conservation Area, a park located 30.2 mi (48.6 km) from the centre of St. Louis.

See properties in August A. Busch Memorial Conservation Area
August A. Busch Memorial Conservation Area

Learn more about Defiance

Defiance is well-known for its attractions such as Yellow Farmhouse Winery and Chandler Hill Vineyards.

See all hotels in Defiance

Check out reviews of Defiance hotels guests love

Relax Inn Saint Charles

Relax Inn Saint Charles

10/10 Excellent
"Privacy, nice people"
Christopher 1-night trip
Posted 2 days ago
Relax Inn Saint Charles

Frequently asked questions

What hotels do travelers recommend in Defiance?
Guests like The Wildwood Hotel.
Can I book refundable accommodations in Defiance?
If you need the flexibility to change your plans to Defiance, most hotels offer refundable* rates you can book. You can find these accommodations by searching our site and using the "fully refundable" filter to narrow down the results.
What will the weather in Defiance be like during my vacation?
July and August are typically the warmest months in Defiance when the average temp is 76°F. January and February are the coldest months when the average temperature is 38°F. May and April are the months with the most rain.
Why should I book my Defiance hotel through Hotels.com?
There are lots of reasons to book your Defiance trip with us: our free cancellations on selected hotels gives you flexibility, and with One Key™, our rewards program, you will be able to earn and use OneKeyCash™* on all eligible bookings such as hotels, car rentals, flights, vacation rentals and more on Hotels.com, Expedia and Vrbo.