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Hotels in Defiance

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Tonight
Oct 27 - Oct 28
Tomorrow
Oct 28 - Oct 29
This weekend
Oct 31 - Nov 2
Next weekend
Nov 7 - Nov 9

Where to stay in Defiance?

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Sleep Inn & Suites O'Fallon MO - Technology Drive
Sleep Inn & Suites O'Fallon MO - Technology Drive
2.5 star property
8.8 out of 10, Excellent, (1006)
The price is $87
$103 total
includes taxes & fees
Nov 2 - Nov 3
Sleep Inn & Suites O'Fallon MO - Technology Drive
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Top landmarks in Defiance

Wetlands landscape with a bird blind and cloudy sky reflected in a lake at the August A. Busch Memorial Conservation Area in St. Charles County Missouri

August A. Busch Memorial Conservation Area

If you like spending time outside, why not spend the afternoon at August A. Busch Memorial Conservation Area, a park located 30.2 mi (48.6 km) from the center of St. Louis.
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Missouri wineries have some of the most superb wine we've ever tasted! We recommend sipping on some chambourcin while basking in the sunshine.
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Chandler Hill Vineyards

Travelers might want a tour of Chandler Hill Vineyards, just one of the places to visit, and located 1.3 mi (2.1 km) from central Defiance.
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Learn more about Defiance

Defiance is well-known for its attractions such as Yellow Farmhouse Winery and Chandler Hill Vineyards.

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Check out reviews of Defiance hotels guests love

Hyatt Place St. Louis/Chesterfield

Hyatt Place St. Louis/Chesterfield

10/10 Excellent
"Great friendly staff, and very accommodating "
Michelle 3-night trip
Posted 3 days ago
Hyatt Place St. Louis/Chesterfield

Frequently asked questions

What hotels do travelers recommend in Defiance?
Guests like The Wildwood Hotel.
Can I book refundable accommodations in Defiance?
If you need the flexibility to change your plans to Defiance, most hotels offer refundable* rates you can book. You can find these accommodations by searching our site and using the "fully refundable" filter to narrow down the results.
What will the weather in Defiance be like during my vacation?
July and August are typically the warmest months in Defiance when the average temp is 76°F. January and February are the coldest months when the average temperature is 38°F. May and April are the months with the most rain.
Why should I book my Defiance hotel through Hotels.com?
There are lots of reasons to book your Defiance trip with us: our free cancellations on selected hotels gives you flexibility, and with One Key™, our rewards program, you will be able to earn and use OneKeyCash™* on all eligible bookings such as hotels, car rentals, flights, vacation rentals and more on Hotels.com, Expedia and Vrbo.

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