Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Commune with nature and explore the great outdoors at Isla Diablo during your travels in San Blas Islands. Take in the festivals while you're in the area.
Museum of the Kuna Nation is 0.3 mi (0.5 km) from central Masargantupo, why not stop by during your stay. If you want to experience more of the culture Masargantupo has to offer, head to Cayos Holandeses.
Commune with nature and explore the great outdoors at Isla Chichime during your travels in San Blas Islands. Take in the festivals while you're in the area.
You can spend time browsing the exhibits at Porvenir Museum during your travels in Narganá. Amble around the area's seaside or experience its festivals.
Eastern Panama is well-known for its attractions such as Cayos Holandeses and Chagres National Park. The city has something for everyone including sights like Darien National Park and Portobelo National Park within a tropical setting.
Check out reviews of Eastern Panama hotels guests love
Ordovician Beach Resort
10/10 Excellent
"The Ordovician Hotel is a hidden gem on the peaceful west side of Isla Grande. From the moment we booked, the service was personal and seamless—thank you, Yohan! We were welcomed by name, greeted with a delicious tropical drink, and felt like cherished guests from start to finish.
We stayed in the Peacock Room, which had stunning views of the pool, restaurant, and beach. The room was beautifully curated, with luxurious bedding, high-end amenities, and thoughtful touches like a handwritten welcome card.
The food was phenomenal, fusing Panamanian flavors with Asian influences—fresh, flavorful, and unforgettable. Special thanks to Sebastián, Chef Stiven, and the entire team for making every meal a delight.
The outdoor massage on the yoga deck overlooking the ocean was magical, and we loved relaxing in the sauna, cold plunge, and hammocks under shaded palapas. We even extended our stay an extra day!
A heartfelt thank-you to Rick and Loan for their vision, presence, and commitment to uplifting Panamanian talent. This place is more than a hotel—it’s an experience of luxury, soul, and connection.
"
"Such a beautiful place! Lovely view and very close to access to the beach. 5 min small boats ride. Relaxing environment mixing mountain feeling and beach view. Very cozy for family of 2 kids. The people in charge there are exceptional! "
"Please fix my Expedia mobile app. It hasn’t worked for several days. The error message says the problem is at Expedia’s end. I have reported this issue by phone but nothing is being done."
Can I book refundable accommodations in Eastern Panama?
If you want the flexibility to change your plans to Eastern Panama, most hotels provide refundable* rates you can book. You can find these properties by searching our site and using the "fully refundable" filter to narrow down the results.
Where can I stay in Eastern Panama if I want a vacation rental instead of a traditional hotel?
If you're looking for a good alternative to a hotel, look over our selection of 14 vacation homes. You can also book one of the 16 cabins for your stay.
Why should I book my Eastern Panama hotel with Hotels.com?
There are plenty of reasons to book your Eastern Panama travel with us: our free cancellations on selected hotels gives you the flexibility you're looking for, and with One Key™, our rewards program, you will be able to earn and use OneKeyCash™* on all eligible bookings such as hotels, car rentals, flights, vacation rentals and more on Hotels.com, Expedia and Vrbo.
