Hotels in Southeast Missouri

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Check prices for these dates

Tonight
Jul 18 - Jul 19
Tomorrow
Jul 19 - Jul 20
This weekend
Jul 18 - Jul 20
Next weekend
Jul 25 - Jul 27

Where to stay in Southeast Missouri?

Drury Inn & Suites Hayti Caruthersville
Relax in our spacious lobby with a seating area, fireplace, and stunning views.

Drury Inn & Suites Hayti Caruthersville

3.0 star property
9.4 out of 10, Exceptional, (1001)
The price is $94
$107 total
includes taxes & fees
Aug 1 - Aug 2
Drury Inn & Suites Hayti Caruthersville
Pear Tree Inn Sikeston
Relax in the spacious lobby with a mezzanine level, comfortable seating, and large windows.

Pear Tree Inn Sikeston

2.5 star property
9.4 out of 10, Exceptional, (1002)
The price is $80
$92 total
includes taxes & fees
Jul 20 - Jul 21
Pear Tree Inn Sikeston
Drury Inn & Suites Jackson MO
Relax in the hotel's spacious lobby, featuring a comfortable seating area with a sofa, coffee tables, and chairs.

Drury Inn & Suites Jackson MO

3.0 star property
9.6 out of 10, Exceptional, (1002)
The price is $90
$95 total
includes taxes & fees
Jul 22 - Jul 23
Drury Inn & Suites Jackson MO
Postcard Cabins St. Francois
Situated in a wooded area, this cabin features a cozy outdoor space with a porch, bench, fire pit, and table.

Postcard Cabins St. Francois

2.0 star property
10.0 out of 10, Exceptional, (17)
The price is $89
$133 total
includes taxes & fees
Jul 21 - Jul 22
Postcard Cabins St. Francois
Drury Inn & Suites Poplar Bluff
Relax in the spacious lobby with a reception desk, seating area, and large windows.

Drury Inn & Suites Poplar Bluff

3.0 star property
9.2 out of 10, Wonderful, (884)
The price is $94
$106 total
includes taxes & fees
Aug 17 - Aug 18
Drury Inn & Suites Poplar Bluff
Microtel Inn & Suites by Wyndham Sainte Genevieve
Relax in this stylish room with two single beds, a flat-screen TV, and a desk for work or relaxation.

Microtel Inn & Suites by Wyndham Sainte Genevieve

2.5 star property
8.8 out of 10, Excellent, (580)
The price is $86
$97 total
includes taxes & fees
Jul 20 - Jul 21
Microtel Inn & Suites by Wyndham Sainte Genevieve
Hampton Inn Poplar Bluff
Relax in the serene patio area surrounded by lush greenery and a charming gazebo.

Hampton Inn Poplar Bluff

2.5 star property
9.4 out of 10, Exceptional, (740)
The price is $97
$109 total
includes taxes & fees
Aug 10 - Aug 11
Hampton Inn Poplar Bluff
Drury Inn & Suites Sikeston, MO
Relax in the serene courtyard, surrounded by lush greenery and comfortable seating.

Drury Inn & Suites Sikeston, MO

3.0 star property
9.4 out of 10, Exceptional, (1002)
The price is $102
$117 total
includes taxes & fees
Jul 27 - Jul 28
Drury Inn & Suites Sikeston, MO
Pear Tree Inn Cape Girardeau West
Welcome to our reception area, featuring a modern reception desk and a cozy seating area with armchairs.

Pear Tree Inn Cape Girardeau West

2.5 star property
9.0 out of 10, Wonderful, (1003)
The price is $70
$79 total
includes taxes & fees
Jul 20 - Jul 21
Pear Tree Inn Cape Girardeau West
Fairfield Inn & Suites by Marriott Poplar Bluff
Relax in the spacious lobby with a stone fireplace, comfortable seating, and a large window.

Fairfield Inn & Suites by Marriott Poplar Bluff

2.5 star property
9.4 out of 10, Exceptional, (773)
The price is $99
$112 total
includes taxes & fees
Aug 3 - Aug 4
Fairfield Inn & Suites by Marriott Poplar Bluff
The Riverview
Relax in a stylish room with two beds, a desk, and a city view.

The Riverview

2.0 star property
9.4 out of 10, Exceptional, (346)
The price is $117
$132 total
includes taxes & fees
Jul 20 - Jul 21
The Riverview
Holiday Inn Express & Suites Perryville by IHG
Welcome to our reception area, where guests can check in at the digital station and enjoy the vibrant artwork.

Holiday Inn Express & Suites Perryville by IHG

2.5 star property
9.4 out of 10, Exceptional, (484)
The price is $101
$116 total
includes taxes & fees
Jul 20 - Jul 21
Holiday Inn Express & Suites Perryville by IHG
Hampton Inn Cape Girardeau I 55 East
Relax in style with comfortable seating and social tables amidst a clean, modern space.

Hampton Inn Cape Girardeau I 55 East

2.5 star property
9.6 out of 10, Exceptional, (727)
The price is $110
$124 total
includes taxes & fees
Jul 27 - Jul 28
Hampton Inn Cape Girardeau I 55 East
Tru By Hilton Cape Girardeau
Enjoy a spacious room with a large bed, desk, and seating area, featuring a flat-screen TV and a desk lamp.

Tru By Hilton Cape Girardeau

2.5 star property
9.6 out of 10, Exceptional, (43)
The price is $93
$105 total
includes taxes & fees
Jul 27 - Jul 28
Tru By Hilton Cape Girardeau
The Farmstead Hotel
Welcome to The Farmstead, where a symmetrical facade and central entrance invite you in.

The Farmstead Hotel

2.5 star property
8.8 out of 10, Excellent, (383)
The price is $95
$108 total
includes taxes & fees
Jul 19 - Jul 20
The Farmstead Hotel
Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG
Relax in the stylish lobby, featuring a fireplace, comfortable seating, and a large flat-screen TV.

Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG

2.5 star property
9.4 out of 10, Exceptional, (1001)
The price is $101
$114 total
includes taxes & fees
Aug 8 - Aug 9
Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG
Pinemark Inn & Suites
Welcome to Pinnacle, where a grand entrance and spacious balconies await.

Pinemark Inn & Suites

2.0 star property
9.6 out of 10, Exceptional, (1001)
The price is $139
$153 total
includes taxes & fees
Jul 21 - Jul 22
Pinemark Inn & Suites
Drury Inn & Suites Cape Girardeau
Reception area with a reception desk, flat-screen TV, and seating area.

Drury Inn & Suites Cape Girardeau

3.0 star property
9.4 out of 10, Exceptional, (957)
The price is $90
$102 total
includes taxes & fees
Jul 24 - Jul 25
Drury Inn & Suites Cape Girardeau
Drury Plaza Hotel Cape Girardeau Conference Center
Relax in a stylish lounge area with a curved sofa, coffee table, and large flat-screen TV.

Drury Plaza Hotel Cape Girardeau Conference Center

3.0 star property
9.6 out of 10, Exceptional, (1005)
The price is $90
$102 total
includes taxes & fees
Jul 22 - Jul 23
Drury Plaza Hotel Cape Girardeau Conference Center
Fairfield Inn & Suites by Marriott Cape Girardeau
Enjoy meals around the large dining table, surrounded by comfortable seating for four.

Fairfield Inn & Suites by Marriott Cape Girardeau

2.5 star property
9.4 out of 10, Exceptional, (114)
The price is $93
$105 total
includes taxes & fees
Jul 27 - Jul 28
Fairfield Inn & Suites by Marriott Cape Girardeau
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Top landmarks in Southeast Missouri

Taum Sauk Mountain in located in the St.Francis mountain range of south/central Missouri. It's also the highest point in Missouri. My kids are standing at the spot where the actual marker sign in

Elephant Rocks State Park

Elephant Rocks State Park is 5.3 mi (8.5 km) from central Ironton, why not stop by during your stay.

See properties in Elephant Rocks State Park
Elephant Rocks State Park

Learn more about Southeast Missouri

Southeast Missouri is well-known for its wineries and riverfront while attractions include Sam A. Baker State Park and K Bridge Recreation Area. This family-friendly city has something for everyone including its university life, restaurants, and sights like Lake Wappapello State Park and Clearwater Lake.

See all hotels in Southeast Missouri

Check out reviews of Southeast Missouri hotels guests love

The Riverview

The Riverview

10/10 Excellent
"Just pretty and cozy smelled nice "
Courtney 2-night trip
Posted 6 hours ago
The Riverview

Frequently asked questions

Can I book a refundable accommodation in Southeast Missouri?
If you need the flexibility to change your travel plans to Southeast Missouri, most hotels provide refundable* rates you can book. You can see these accommodations by searching our site and using the "fully refundable" filter to narrow the results down.
Where can I stay in Southeast Missouri if I want a vacation home instead of a traditional hotel?
If you want a good alternative to a hotel, look over our selection of 129 vacation homes. In addition, there are 46 apartments and 7 condos.
Why should I book my Southeast Missouri accommodation with Hotels.com?
There are plenty of reasons to book your Southeast Missouri travel with us: our free cancellations on selected hotels gives you the flexibility you're looking for, and with One Key™, our rewards program, you will be able to earn and use OneKeyCash™* on all eligible bookings such as hotels, car rentals, flights, vacation rentals and more on Hotels.com, Expedia and Vrbo.